Nitric Oxide Services, LLC

Nitric Oxide Services, LLC – CLIA-Certified NO Diagnostics & R&D Lab

Validated NO science, done right

Validated nitric oxide analytics and translational R&D—done right, done fast.

We specialize in nitric oxide (NO) and one-carbon metabolism: chemiluminescence (NOx), Franz-cell permeation, high-throughput NO-release kinetics, and CLIA-grade diagnostics to move your science from idea to impact.

CLIA-certified • ICH-aligned workflows

NOx by V(III) Chemiluminescence — serum, plasma, tissue, produce.
Franz-Cell Permeation — dermal/transmucosal delivery with GLP-style docs.
NO-Release Kinetics — hydrogels, nanoparticles, coated devices.
One-Carbon Metabolism — folate/B12 analytics & NO‑Cbl programs.

Brief overview of our validated NO science.

Our Services

Direct support from discovery through validation and clinical translation.

Validation

Device & Coating Validation

ICH M10–aligned assays for topical/in vivo NO; evaluation of NO‑based coatings for implant protection.

Regulatory

New Drug & Supplement

ICH‑guided assay support to back R&D, clinical, and commercial needs.

Patent & Trademark Strategy

Searches and patentability landscape (novelty/obviousness) to inform development.

Preclinical

Wound‑Healing & PK/PD

IACUC‑approved studies; pharmacokinetic/dynamic programs for NO donors.

Clinical Design

Wearables & Exercise Science

Trial design using ACSM guidelines for devices assessing nitric oxide.

Analytics

Bioanalytical NO Panels

NO/NO₂, nitrate/nitrite/nitrosothiols, NO‑heme, and NO‑metals across matrices.

In Vitro

Cytotoxicity & Viability

Dose/time‑response & ID₅₀ for gaseous NO and NO donors in mammalian/prokaryotic systems.

Chemistry

Custom NO‑Donor Synthesis

GLP→cGMP scale synthesis; kinetic profiling by HPLC, UV/Vis, FTIR, chemiluminescence.

Custom

Fit‑for‑Purpose Projects

Bespoke studies/methods tailored for NO delivery across healthcare applications.

Management Team

Leadership spanning nitric oxide chemistry, translational research, veterinary medicine, and IP strategy.

President

Joseph A. Bauer, Ph.D.

Translational scientist (former Cleveland Clinic Taussig Cancer Institute). >29 yrs in NO chemistry/biochemistry; >20 yrs in cancer medicine; >$5M in NIH/NCI & foundation support; multiple patents; 100+ abstracts/manuscripts.

Profiles: Google Scholar · ORCID

VP & Director of R&D

Annette M. Sysel, DVM, MS

30+ yrs in private & academic veterinary medicine; epidural catheterization used in care of 2006 Kentucky Derby winner Barbaro; grants (AKC, Winn Feline Foundation, Blue Buffalo); FDA CVM & pre‑IND for NO‑Cbl; 2015 American HERO Veterinarian.

Director, Innovation & Tech Transfer

Weisun Rao, J.D., Ph.D.

Managing Partner at Venture Partner, LLC; former partner at Greenberg Traurig. IP & business law, cross‑border M&A, licensing, FTO, and portfolio strategy across pharma/biotech/devices/materials/nutraceuticals.

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